Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors
نویسندگان
چکیده
منابع مشابه
Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors
The modulation of PPIs by low molecular weight chemical compounds, particularly by orally bioavailable molecules, would be very valuable in numerous disease indications. However, it is known that PPI inhibitors (iPPIs) tend to have properties that are linked to poor Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) and in some cases to poor clinical outcomes. Previously repor...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/srep46277